New Grafting Technique Regenerates Bones From Cartilage

Researchers from the Orthopaedic Trauma Institute have found a method that is more effective for integration.

Researchers from the Orthopaedic Trauma Institute at the University of California in San Francisco have found a promising new way to regenerate bone. A cartilage graft introduces bone that integrates really well with the person’s own bone, producing new tissue that is very similar to the existing tissue and fully vascularized.

The current methods used for bone grafting can result in poor integration and osteonecrosis (bone death caused by poor blood supply). This new procedure has the potential to enhance patient care and clinical outcomes. According to MedicalXpress, cartilage grafts produce new tissue similar to the person’s own bone through a process called “endochondral ossification.” Chelsea S. Bahney, PhD, postdoctoral scholar at UCSF School of Medicine, said:

This cartilage is naturally bioactive. It makes factors that help induce vascularization and bone formation. When people use a bone graft, it is often dead bone which requires something exogenous to be added to it or some property of the matrix in the graft. Healing of the transplanted cartilage grafts supported our hypothesis by producing a well-vascularized bone that integrated well with the host.

Orthopaedic Trauma Institute

Photo by Susan Merrell

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