Experimental Drug Could Build Lean Muscle Without Exercise

Experimental Drug Could Build Lean Muscle Without Exercise

If successful, the drug SR9009 could potentially help reverse obesity and diabetes.

Leah Gonzalez
  • 21 august 2013

A drug called SR9009 has been found to increase exercise endurance in mice. The drug reportedly increased the metabolic activity in mice muscles and the mice that received the drug exhibited an increase in running capacity, which was measured in terms of time and distance.

The SR9009 drug is one of two compounds developed in the laboratory of Thomas Burris, professor at The Scripps Research Institute (TSRI). The compounds were found to have reduced obesity in animal models, as described in a paper published on the Nature online journal in March this year.

The drug works by attaching itself to Rev-erbα, a nuclear receptor that influences fat and sugar metabolism in the liver, fat-storing cell production, and the response of the body during inflammation.

In the study with SR9009, the researchers used the drug to activate Rev-erbα and the drug helped increase the metabolic activity in the skeletal muscles of the mice. According to Burris, the mice gained muscles like that of ‘an athlete who has been training.’

The pattern of gene expression after treatment with SR9009 is that of an oxidative-type muscle— again, just like an athlete.

According to the researchers, SR9009 has the potential to be beneficial to patients who suffer from conditions such as obesity, diabetes, congestive heart failure, and chronic obstructive pulmonary disease–conditions that limit the patients’ tolerance for exercise.

The study, published in Nature Medicine in July, was conducted by researchers from the Institut Pasteur de Lille in France, TSRI, Université Lille Nord de France, and Maastricht University Medical Center in the Netherlands. It was supported by various grants.

The Scripps Research Institute

Image via TSRI


Dubai And The Future Of Humanitarian Design

Design & Architecture
Technology october 21, 2016

Concept Camera Designed To Only Take Unique Photos

Camera Restricta is tool that prompts photographers to only capture one-of-a-kind images

Design & Architecture october 21, 2016

Fragrance Will Release The Smell Of Data If Your Private Information Is Being Leaked

The device is designed to create a physical cue for the potential dangers lurking online


Get PSFK's Related Report: Sports Debrief

See All
Retail october 21, 2016

LYNK & CO Is A New Auto Brand That Promises Mobile Connectivity On Wheels

Online access and mobility sharing are driving the company to disrupt the auto industry

Related Expert

Sabrina Caluori

Television, Social Media, Marketing

Travel october 21, 2016

Become A Citizen Of The First Nation In Space

Asgardia is a new concept for a floating society above Earth

Entertainment october 21, 2016

Speaker Displays Song Lyrics As Music Is Played

The device is able to generate the graphics on a translucent screen and retrieve the words from a connected database

AI october 21, 2016

Travel Assistant Scans Your Emails To Make Planning Easier

This AI add-on will sync with your inbox and sends reminders to make sure you don't miss anything important


Future Of Automotive
Scenarios Driving The Digital Transformation Of An Industry

PSFK Op-Ed october 17, 2016

Home Depot Green Energy Expert: Americans Are Taking Control Of Their Power Use

Green tech expert Jennifer Tuohy discusses new home energy tech and developments for renewables in the US

PSFK Labs october 21, 2016

PSFK Picks: Top 5 Performance-Enhancing Wearables

Our new report looks at innovations pioneering the future of performance through intelligent activewear and predictive analytics

Millennials october 21, 2016

FOMO Survival Kit Helps Millennials Cope With Social Anxieties

The satirical product is meant to be a playful diversion for people who feel like they are missing out

Food october 21, 2016

New York Restaurant Uses Tomato Sushi As Its Newest Meat Alternative

fresh&co is using sous vide Roma tomatoes to create a vegan option that has the texture and taste of tuna

Advertising october 21, 2016

Red Bull Converts Sao Paulo Payphones Into Data-Driven Bus Schedules

The booths allow city residents to check local transit times through a simple toll-free phone call

Work october 21, 2016

Health Expert: Nutritional Meal Replacements Are A Solution To Corporate Wellness

Ample Foods Founder Connor Young explains why supplements are the next food trend coming to the workplace

Retail october 21, 2016

Why Experiential Events Could Replace Trade Shows

Marketers are seeking creative and impactful new ways to connect with influencers

Children october 21, 2016

Modular Kit Teaches Kids How To Make Their Own Robots

MODI features magnetic modules and a platform for programming to encourage experimentation

Infants october 21, 2016

Work Table Doubles As A Baby Seat

Designer Kunsik Choi created the furniture to facilitate emotional communication between between parents and their children

Technology october 21, 2016

Album Turns Into Something New Each Time It’s Streamed

Bill Baird's new album explores the relationship between time and music through a website crafted by design team, One Pixel Wide

No search results found.