Enzyme inhibition makes mice more adaptive to environmental changes

Time zone changes and irregular working patterns can wreak havoc on our bodies, but a team from the University of Manchester may have found a solution. When a certain enzyme in the body was inhibited, mice were able to adapt to a new environment much more quickly than before. It could mean a new drug that makes it easier for frequent fliers and shift workers to adapt to constant change.

“We are not genetically pre-disposed to quickly adapt to shift-work or long-haul flights, and as so our bodies' clocks are built to resist such rapid changes,” says Dr David Bechtold, the scientist who led a University of Manchester team that worked with in collaboration with Pfizer “Unfortunately, we must deal with these issues today, and there is very clear evidence that disruption of our body clocks has real and negative consequences for our health.”

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